Antivirals

US 11,214,570 A novel pyrrolopyridine compound represented by Chemical Formula I, a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and a method for preparing the same. The compound shows high selectivity and antiviral activity against human immunodeficiency virus (HIV), with low toxicity, and is useful as a therapeutic agent for viral infection; in particular, HIV infection. ST Pharm (Siheung-si, S. Korea) Kim BJ, Lee IY, Kim JH, Shin HS, Son JC, Lee C-K, Kim K, Kim U-I, Nam HJ 1/4/2022 US 11,208,427 Dicaffeoyl spermidine derivative glycosides, a preparation method and a use thereof. The dicaffeoyl spermidine derivative glycosides have antioxidative activity and antiviral activity, and can be used as an antioxidant for the prevention and/or treatment of neurodegenerative diseases such as senile dementia, and as an antiviral agent for the prevention and/or treatment of viral infections. Jinan University (Guangdong, China) Gao H, Yao X, He R, Chen G, Zhou Z, Wang C, Hu D, Fan H 12/28/2020 US 11,198,693 Compounds of Formula I, or pharmaceutically acceptable salts thereof, which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle and are also useful as antiviral agents. Also, methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds. Enanta Pharmaceuticals (Watertown, MA, USA) Panarese J, Davis D, Bartlett S, Chong K, Kenton N, Or YS 12/14/2021 US 11,192,875 Processes for the preparation of a compound of the specified structural formula, which is useful as an antiviral agent. Also, compounds that are synthetic intermediates. Gilead Pharmasset (Foster City, CA, USA) Allan KM, Fujimori S, Heumann LV, May G, Brown KA, Levins CM, Pamulapati GR, Roberts BJ, Sarma K, Teresk MG, Wang X, Wolckenhauer SA 12/7/2021 US 11,186,835 Artificial ribosomes that synthesize nonribosomal peptides, polyketides and fatty acids with full control over peptide sequence. Also, methods for programmed synthesis of nonribosomal peptides, polyketides and fatty acids, and methods for scalable synthesis of a wide range of antibacterial, antifungal, antiviral and anticancer compounds. Arizona Board of Regents on behalf of Arizona State University (Scottsdale, AZ, USA) Green AA 11/30/2021 US 11,185,493 A bactericidal, antiviral composition including betel leaf extracts or essential oils in combination with at least two active ingredients of the plant extracts, a 4-allylpyrocatechol ingredient, a camphor ingredient, a water paraffin ingredient, an alcohol ingredient, other ingredients and a water ingredient. Huynh TK Huynh TK, Huynh NL 11/30/2021 US 11,174,482 An antiviral agent having a phosphorodiamidate morpholino oligomer with an antisense sequence to a portion of a genome of a strain of Zika virus (ZIKV). Useful as a pharmaceutical composition, a method of treating ZIKV-mediated disease, a method of preventing ZIKV-mediated disease, a method of reducing or preventing the replication of ZIKV in a host cell, a method of controlling the spread of ZIKV in donated tissue or a treated tissue sample, and in the manufacture of a medicament for the treatment or prevention or ZIKV-mediated disease. Meharry Medical College (Nashville, TN, USA) Alcendor DJ, Popik W 11/16/2021 US 11,155,582 An antiviral peptide provided that includes (i) an amino acid sequence constituting a transmembrane region of G protein of vesicular stomatitis virus (VSV) or a modified amino acid sequence formed by conservative substitutions of 1, 2 or 3 amino acid residues in the transmembrane sequence; and (ii) an amino acid sequence functioning as a cell-penetrating peptide, wherein the total number of amino acid residues is 100 or fewer. Toagosei Co. Ltd. (Tokyo), National University Corporation Hokkaido University (Sapporo, Japan) Yoshida T, Takada A, Baileykobayashi N 10/26/2021