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British scientists, analyzing data from the British Biobank, confirmed the existing scientific opinion that the manifestations of allergies are often accompanied by mental disorders. The mathematical processing of the results of genetic analyzes, performed by the method of Mendel randomization, does not reveal a causal relationship between these two groups of diseases. The study was published in the journal Clinical and Experimental Allergy of the British Society of Allergy and Clinical Immunology.
) Previous studies have shown a visible link between mental health and common allergic conditions such as asthma, atopic dermatitis and hay fever, but the nature of this link remains unclear. In addition, some researchers note that people with allergic diseases are generally more prone to depression, anxiety, bipolar disorder and neuroticism, but this does not mean that mental disorders are caused by allergies or vice versa.
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To analyze independently manifestations of the two groups of diseases, researchers from the Universities of Bristol and Edinburgh used the Mendel randomization method to process patient data from UK Biobank. This allowed them to identify genetic variants that determine specific allergic conditions and then test for links to mental disorders.
It turned out that stable links between allergic diseases and mental health characteristics do exist, but they are not traced in a special causal analysis, ie none of groups of diseases do not play a significant role in the emergence of the other.
“We found convincing evidence of a link between the phenotypes of allergic disease and depression, anxiety, bipolar disorder and neuroticism. Similar links have been found between asthma, atopic dermatitis, hay fever and mental health phenotypes. But there is little evidence of causal – investigative connection between them “, write the authors of the article.
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