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New DNA Sensor Quickly Determines Whether Viruses Are Infectious

New Sensor Can Distinguish Infectious Viruses From Noninfectious

A new sensor can distinguish infectious viruses from noninfectious ones thanks to selective DNA fragments and sensitive nanopore technology. Credit: Image courtesy of Ana Peinetti

A new sensor can detect not only whether a virus is present, but whether it’s infectious – an important distinction for containing viral spread.

Researchers at the University of Illinois Urbana-Champaign and collaborators developed the sensor, which integrates specially designed

DNA Aptamers Bind Selectively to Infectious Viruses

DNA aptamers bind selectively to infectious viruses. In addition to the nanopore sensor, they could be integrated into other platforms such as color-changing dipsticks. Credit: Image courtesy of Ana Peinetti

The “gold standard” of viral detection, PCR tests detect viral genetic material but cannot distinguish whether a sample is infectious or determine whether a person is contagious. This can make it more difficult to track and contain viral outbreaks, the researchers said.

“With the virus that causes COVID-19, it has been shown that the level of viral DOI: 10.1126/sciadv.abh2848

This work was supported by a RAPID grant from the National Science Foundation and a seed grant from the Institute for Sustainability, Energy, and Environment at Illinois and the Illinois-JITRI Institute. Peinetti was supported by the PEW Latin American Fellowship.

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