Browsing Tag
Antibodies
4 posts
LBCL: Bispecific Antibodies Fare Less Well in Real-World Analysis
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Bispecific Antibodies in Relapsed/Refractory DLBCL
Follow-up data from the EPCORE NHL-1 trial lend further support to the efficacy and safety of single-agent epcoritamab (Epkinly) in the treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL), according to a presentation at the American Society of Clinical Oncology (ASCO) annual meeting. MedPage Today brought together three expert leaders in the field: Moderator Ian
Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors
AbstractSmall molecules that stabilize inactive protein conformations are an underutilized strategy for drugging dynamic or otherwise intractable proteins. To facilitate the discovery and characterization of such inhibitors, we created a screening platform to identify conformation-locking antibodies for molecular probes (CLAMPs) that distinguish and induce rare protein conformational states. Applying the approach to KRAS, we discovered…
Do Monoclonal Antibodies Help COVID Patients?
As COVID deaths continue to spike across the U.S.—primarily among unvaccinated populations—newly developed treatments for the disease are again receiving attention. Monoclonal antibody (mAb) therapies are among the most effective. In this treatment, patients are infused with high concentrations of antibodies specifically engineered to fight SARS-CoV-2, the virus that causes COVID. These treatments have been…