Browsing Tag
Partitioning
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Partitioning RNAs by length improves transcriptome reconstruction from short-read RNA-seq data
AbstractThe accuracy of methods for assembling transcripts from short-read RNA sequencing data is limited by the lack of long-range information. Here we introduce Ladder-seq, an approach that separates transcripts according to their lengths before sequencing and uses the additional information to improve the quantification and assembly of transcripts. Using simulated data, we show that a…