Browsing Tag
transposition
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Nanobody-tethered transposition enables multifactorial chromatin profiling at single-cell resolution
MainSeveral related methods were recently developed that enable individual aspects of chromatin state to be measured at single-cell resolution via an antibody-guided DNA tagmentation reaction1,2,3. However, chromatin states are characterized by combinations of factors at an individual locus4, including histone post-translational modifications and the binding of non-histone proteins to the DNA. For example, promoters are