Browsing Tag
Massively
2 posts
Massively parallel phenotyping of coding variants in cancer with Perturb-seq
AbstractGenome sequencing studies have identified millions of somatic variants in cancer, but it remains challenging to predict the phenotypic impact of most. Experimental approaches to distinguish impactful variants often use phenotypic assays that report on predefined gene-specific functional effects in bulk cell populations. Here, we develop an approach to functionally assess variant impact in single…
Massively Reducing Food Waste Could Feed the World
Imagine going to the market, leaving with three full bags of groceries and coming home. Before you step through your door, you stop and throw one of the bags into a trash bin, which later is hauled away to a landfill. What a waste. Collectively, that is exactly what we are doing today. Globally, 30…