Browsing Tag
therapeutic
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A new therapeutic target for the prevention of heart failure due to aortic stenosis
Cardiomyocyte-specific human β3AR overexpression prevents cardiomyocyte hypertrophy upon catecholamine challenge via NO/cGMP pathway. A Genetic constructs for adeno-associated virus (AAV) vectors encoding hβ3AR and control EGFP. ITR, recognition site for AVV packaging; Cmr4, enhancer sequence; Prom cTnT, troponin T promoter sequence for cardiomyocyte-specific expression; ADRB3, human β3AR receptor cDNA sequence, EGFP enhanced green fluorescent protein